Activated Salivary MMP-2 - A Potential Breast Cancer Marker

Nabanita Bhattacharyya1, Subhajit Mondal1, Mohammad Nasim Ali1, Ramanuj Mukherjee2, Anjan Adhikari2, Amitava Chatterjee1, *
1 Ramakrishna Mission Vivekananda University, Narendrapur, Kolkata, India
2 R G Kar Medical College, Kolkata, India

© 2017 Bhattacharyya

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Emeritus Scientist, Ramakrishna Mission, Vivekananda University, Narendrapur, Kolkata-700103, India; Tel/Fax: 033-2477-2020; E-mail:


It has been reported that Matrixmetalloproteinase-2 (MMP-2) is involved in the pathogenesis of cancer. The over expression of MMP-2 is associated with the progression of malignancy of several types of carcinoma. Human saliva is a biological fluid with several advantages for non-invasive diagnosis and prognosis of diseases. The aim of this study was to detect MMPs expression and activity in biological fluids (saliva, urine etc.) derived from breast cancer patients. Here, our results showed that the activity of MMP-2 was higher at the time before the surgery than after the saliva collected from the same patients. Therefore, we suggested that the highly active form of MMP-2 presented in saliva could be used as a novel potential biomarker for non-invasive diagnosis of breast cancer.

Keywords: Saliva, MMP-2, non invasive, breast cancer.