RESEARCH ARTICLE


Computer Aided Formulation and Characterization of Propranolol Hcl Buccal Tablet Using Polymeric Blend



Sana Hanif1, Nadeem Irfan2, Zeeshan Danish2, *, Nisaar Hussain3, Muhammad Ali1, Bushra Nasir3, Javed Iqbal1, Hamid Saeed3, Rubina Ali1, Zikria Saleem2
1 Department of Pharmacy, University of Lahore, Lahore, Pakistan
2 University College of Pharmacy, University of the Punjab, Lahore, Pakistan
3 Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan


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© Hanif et al; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the University College of Pharmacy, University of the Punjab, Lahore, Pakistan; Tel: +92-426169211, +92321-4041222; E-mail: pfarmacist@hotmail.com


Abstract

The current study was aimed to formulate a continuous release mucoadhesive buccal tablet containing propranolol HCl. The type and quantities of polymers as well as method of compression were set in a preliminary study (F1-F13). Direct compression method was employed in the main study (F14-F24) using Carbopol® 934P (CP), ethylcellulose (EC), sodium alginate (SA), hydroxypropyl methylcellulose (HPMC k4M) and carboxymethylcellulose (CMC) as mucoadhesive polymers and were tested for physicochemical tests i.e. swellability, surface pH, mucoadhesive time, mucoadhesive strength, in vitro release etc. Results obtained from the study were optimized using NeuralPower® 3.1, an artificial intelligence approach. Against the desirability of physico-chemical parameters, the software optimized the ingredients as HPMC (150mg), CMC (25mg), CP (20mg) and EC (20mg). Outcome revealed that HPMC primarily contributed to the physicochemical properties of mucoadhesive formulation. To compare prediction, optimized ingredients were formulated (F25) and tested. The swellability index of confirmation formulation (F25) was 102% at 6 h. As predicted, similar release pattern was of F25 was obtained as 26% (0.5h), 34% (1h), 40% (2h), 45% (3h), 50% (4h), 62% (5h), 76% (6h), 85% (7h) and 97% (8h) respectively. For release kinetics, DD solver® suggested the release of the drug to be non-Fickian.

Keywords: Mucoadhesive buccal tablet, Optimization, propranolol buccal tablet, HPMC, Cellulose.